Webinar on 11/2022

The new leadership team organized a webinar on “Viewing Tissues through a Chemical Lens | Applications of MSI in Biomedical Research” – let’s find out what Mass Spectrometry Imaging can do for you to support your research!


Speakers & Themes

Mass Spectrometry Imaging in Breast Cancer and Parkinson’s Research

Tina received her PhD from the University of Gothenburg, spent three years at the University of Washington and two years at the Luxemburg Institute of Science and Technology, working with various mass spectrometry imaging techniques on biomedical research projects. Now she is a researcher at Uppsala University focusing on DESI-MRM imaging for location specific drug quantification in tissues.

Advancing our Understanding of Drug Delivery using Multimodal Imaging

Nicole studied Chemistry at the Justus Liebig University in Giessen, Germany. She performed her doctoral studies at the Department for Surgery and Cancer at Imperial College London before joining the MSI group at AstraZeneca. In 2021, Nicole was appointed to the assistant professorship for Analytical Chemistry at the Technical University of Munich. Her research focusses on the development and application of in situ and ambient mass spectrometry methods, as well as multimodal imaging to advance our understanding of complex biological systems such as preclinical and clinical tissue specimen or microbial specimen.

Adding another Dimension to your Experiment via Mass Spectrometry Imaging

Alan studied Computer Science at the University of Birmingham, UK, where he also completed his PhD in mass spectrometry imaging. He then joined the National Centre of Excellence in Mass Spectrometry Imaging at the National Physical Laboratory in the UK. In 2017 Alan joined the Institute for Bioanalytical Sciences and Food Analysis at the University of Bayreuth, Germany before moving to the MSI group at AstraZeneca in 2019. Since 2020, he has been at the Institute for Medical Bioinformatics and Biostatistics at the Philipps University of Marburg. His research interests are primarily focussed on developing accurate methods for registering and integrating multi-modal imaging data.

Study Group Scope , Relevance, and Objectives

The scope of the Imaging MS study group is to provide a networking and dissemination platform for molecular imaging researchers and professionals that use mass spectrometry in their daily practice and enables connections to expert in other imaging disciplines.

Multimodal molecular imaging with mass spectrometry is a label-freeimaging modality that has demonstrated enormous potential for pre-clinical and biomedical research. IMS combines the molecular analytic properties of MS with the spatial information obtained by traditional histology, thereby enabling molecular information to be correlated to tissue morphology. This correlation enables a deeper understanding of tissue complexity and the pathophysiological processes underlying disease. As such, IMS enables direct targeted and/or untargeted analysis of endogenous metabolites, oligosaccharides, lipids, peptide and proteins, as well as exogenous compounds (i.e. pharmaceuticals, anti-cancer drugs). The subsequent identification and quantification of potential markers can contribute to generating disease-specific molecular profiles.

This study group intends to increase the broader awareness of the technological basis, as well as its clinical and pharmaceutical applications. The study group fosters a knowledge base where people can learn about quantitative aspects and considerations of imaging MS as well as the potential for integration with other imaging modalities such as PET or MRI. The study group welcomes members with an interest in multimodal imaging that allow researchers to explore truly interdisciplinary molecular research. 

The group currently comprises of academic and industrial collaborators expert in various imaging MS-based technologies, fundamental and applied to pre-clinical and clinical research, and strongly encourages interdisciplinary interactions and therefore welcome all members with an interest in other multimodal imaging to join the discussions initiated during the dedicated workshop or during the different sessions.

  • Enable dissemination of imaging MS-based ideas, methods, techniques, protocols and applications.
  • Stimulate interactions with the broader molecular imaging community and integration with other imaging modalities.
  • Ensure COST networking activities (COST Action BM1104) are continued in the ESMI professional environment.

Group Review Article

Mass Spectrometry Imaging and Integration with Other Imaging Modalities for Greater Molecular Understanding of Biological Tissues
Porta Siegel, T., Hamm, G., Bunch, J., Cappell, J., Fletcher, J.S., Schwamborn, K.

Group Leadership

  • Chair: Alan Race, Marburg
  • Co-Chair: Nicole Strittmatter, Munich
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